An Icelandic pangenome reference.

Reference bias is an issue that affects most genomic studies analysing short reads mapped to a reference genome 1,2 .

Reference bias is an issue that affects most genomic studies analysing short reads mapped to a reference genome 1,2 . It can be mitigated by mapping to multiple haplotypes represented in a pangenome 3-5 . Here we introduce two new methods to address reference bias: Emblask for…