Cleavage of the catalytic intermediate fine-tunes cGAS signalling

Excessive activation of cyclic GMP-AMP synthase (cGAS) drives inflammatory and autoimmune diseases, but complete inhibition of cGAS signaling can compromise host defence.

Excessive activation of cyclic GMP-AMP synthase (cGAS) drives inflammatory and autoimmune diseases, but complete inhibition of cGAS signaling can compromise host defence. Here we show that cGAS signaling can be tuned through a previously unrecognized regulatory checkpoint.…