Super-resolution imaging with deep learning-based segmentation for detailed characterization of mitochondrial arrangement in Pompe disease skeletal muscle

Pompe disease (glycogen storage disease type II) is an autosomal recessive lysosomal storage disorder characterized by progressive glycogen accumulation within lysosomes.

Pompe disease (glycogen storage disease type II) is an autosomal recessive lysosomal storage disorder characterized by progressive glycogen accumulation within lysosomes. It leads to their enlargement, autophagosome build-up and defective autophagic flux. Among the…