Spatial Transcriptomics of Glioblastoma Defines Spatially Anchored Transcriptional Activity Informing Therapeutic Vulnerability and Resistance

Intratumoral heterogeneity is thought to hinder targeted therapy in glioblastoma (GBM), but the extent of variation in known targets and tumor cell-intrinsic and extrinsic regulatory mechanisms within tissue remains unclear.

Intratumoral heterogeneity is thought to hinder targeted therapy in glioblastoma (GBM), but the extent of variation in known targets and tumor cell-intrinsic and extrinsic regulatory mechanisms within tissue remains unclear. In this work, we use Visium spatial transcriptomics to…