Science & ResearchJul 29, 2026
Mitochondrial metabolism and epigenetic crosstalk drive SASP
Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10791-2 In senescent cells, mitochondria-derived acetyl-CoA promotes histone acetylation and increases chromatin accessibility at inflammatory gene loci.
Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10791-2 In senescent cells, mitochondria-derived acetyl-CoA promotes histone acetylation and increases chromatin accessibility at inflammatory gene loci. Inhibition of SLC25A1 attenuates these effects, underscoring…
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