Dual effects of influenza A virus PA-X on suppression of cytokine signaling and MHC I pathway disruption in the human airway epithelium

The mechanisms of immune evasion of influenza A virus are key to its success as an infectious agent.

The mechanisms of immune evasion of influenza A virus are key to its success as an infectious agent. To replicate effectively, influenza A virus must suppress both early innate immune responses, like antiviral type I and III interferons, and adaptive immune responses. The latter…