Science & ResearchJul 23, 2026
UTR-ly unexpected: RNA chaperones tame intrinsically disordered proteins.
How do cells ensure that complex, multidomain proteins fold correctly?
How do cells ensure that complex, multidomain proteins fold correctly? Luo et al. reveal a self-contained solution. The 3' UTR of an mRNA co-translationally chaperones the protein it encodes, preventing intrinsically disordered regions from making inappropriate contacts. This…
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