Type I Natural Killer T Cells Suppress Infection-Induced Cytokine Storm Through an IL-22-STAT3 Axis

Severe infections can trigger systemic inflammatory response syndrome (SIRS), wherein excessive cytokine release generates a cytokine storm causing tissue damage, multi-organ failure, and death.

Severe infections can trigger systemic inflammatory response syndrome (SIRS), wherein excessive cytokine release generates a cytokine storm causing tissue damage, multi-organ failure, and death. Natural killer T (NKT) cells are innate-like lymphocytes that respond rapidly to…