TRIM28 preserves ovarian identity by stabilising lineage-specific transcription factor hubs

Maintenance of ovarian cell identity is required throughout life to prevent the activation of the testicular programme, but the epigenetic mechanisms underlying this process remain poorly understood.

Maintenance of ovarian cell identity is required throughout life to prevent the activation of the testicular programme, but the epigenetic mechanisms underlying this process remain poorly understood. Although TRIM28 is required to prevent granulosa-to-Sertoli…