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Science & ResearchAug 28, 2026

Eplontersen for Transthyretin Amyloid Cardiomyopathy.

Transthyretin amyloidosis with cardiomyopathy (ATTR-CM) is a progressive, life-threatening disease caused by deposition of misfolded transthyretin (TTR).

Transthyretin amyloidosis with cardiomyopathy (ATTR-CM) is a progressive, life-threatening disease caused by deposition of misfolded transthyretin (TTR). Eplontersen, an antisense oligonucleotide, reduces the production of hepatic TTR. The effect of eplontersen on ATTR-CM is…

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