Science & ResearchAug 12, 2026
Rb-driven transcription limits its tumour-suppressive effects in breast cancer
Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10886-w CDK4/6 inhibition redirects Rb chromatin occupancy to activate oestrogen-responsive genes, counteracting its own ability to maintain therapeutic cell-cycle arrest.
Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10886-w CDK4/6 inhibition redirects Rb chromatin occupancy to activate oestrogen-responsive genes, counteracting its own ability to maintain therapeutic cell-cycle arrest.
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