Experiment-anchored abundance coverage frontiers define conditional RHSVV exposure requirements in TP53-missense tumors

Mutant p53 accumulation is established, but whether abundance can complement conditional RHSVV/PAb240-like exposure depends on the trade-off between target coverage and normal tissue separation.

Mutant p53 accumulation is established, but whether abundance can complement conditional RHSVV/PAb240-like exposure depends on the trade-off between target coverage and normal tissue separation. We analyzed 809 tumors and 523 organ-matched adjacent normal specimens from eight…