Science & ResearchAug 25, 2026
DePARylation prevents DNA replication-driven PARP1 condensation
PARG, the primary enzyme responsible for the reversal of PARP1-mediated poly(ADP-ribosyl)ation, has attracted considerable attention as a therapeutic target in cancer.
PARG, the primary enzyme responsible for the reversal of PARP1-mediated poly(ADP-ribosyl)ation, has attracted considerable attention as a therapeutic target in cancer. Yet, the mechanisms underlying PARG inhibitor (PARGi) efficacy remain elusive. Herein, we demonstrate that…
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