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Science & ResearchAug 17, 2026

Dysregulation of the SARA-Smurf2 Regulatory Axis in Temporal Lobe Epilepsy

Temporal lobe epilepsy (TLE) is associated with dysregulation of transforming growth factor {beta} (TGF{beta}) signaling, a key contributor to epileptogenesis.

Temporal lobe epilepsy (TLE) is associated with dysregulation of transforming growth factor {beta} (TGF{beta}) signaling, a key contributor to epileptogenesis. SARA (Smad Anchor for Receptor Activation), a central regulator of this pathway, is controlled by the E3 ubiquitin…

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