CRISPR-Cas regulates expression of embedded anti-phage defence systems.

Bacteria utilize diverse defence systems to protect against harmful foreign DNA such as bacteriophages 1,2 , but how these systems coordinate with each other remains poorly understood.

Bacteria utilize diverse defence systems to protect against harmful foreign DNA such as bacteriophages 1,2 , but how these systems coordinate with each other remains poorly understood. Here we uncover CRISIS (CRISPR-supervised immune system), a widespread regulatory paradigm…