← The frontier
Science & ResearchJul 21, 2026

Limitations of pupil diameter as a proxy for modes of locus coeruleus activity

The locus coeruleus-norepinephrine (LC-NE) system plays multiple roles in higher brain function that are thought to depend on its mode of activation, which reflects relationships between baseline and evoked activation levels.

The locus coeruleus-norepinephrine (LC-NE) system plays multiple roles in higher brain function that are thought to depend on its mode of activation, which reflects relationships between baseline and evoked activation levels. These relationships are evident in both single-unit…

The frontier is open to all. Sign in to learn this from first principles and save it to your knowledge base.