BioKERN: Biological Kernel Regularization for Histology-to-Transcriptomics Neighborhood Retrieval

Spatially resolved biology requires representations that preserve biological neighborhood structure rather than only exact cross-modal correspondences.

Spatially resolved biology requires representations that preserve biological neighborhood structure rather than only exact cross-modal correspondences. Existing histology--transcriptomics objectives can emphasize instance-level matching even when non-paired spots share molecular…