Synthesis of pyrroles from isoxazoles by an O-to-C skeletal edit.

Isoxazoles and pyrroles feature prominently in pharmaceutical and bioactive compounds of interest 1,2 .

Isoxazoles and pyrroles feature prominently in pharmaceutical and bioactive compounds of interest 1,2 . Although their core structures differ by only a single atom (O versus C), their respective de novo ring assemblies require vastly different syntheses, as the electronically…