Identifying endogenous substrates of the 26S proteasome through site-specific photocrosslinking

The 26S proteasome is the hub for regulated protein turnover in eukaryotic cells.

The 26S proteasome is the hub for regulated protein turnover in eukaryotic cells. Degradation of proteins by the Ubiquitin-Proteasome System plays critical roles in every aspect of cell biology, such as the regulation of gene transcription, the quality control of translation and…