Science & ResearchAug 16, 2026
Extravascular coagulation stabilizes pro-fibrotic stromal states via tumor-intrinsic PAR1 signaling in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) exhibits a desmoplastic stroma that can restrain or promote tumor, highlighting the need to selectively reprogram stromal states.
Pancreatic ductal adenocarcinoma (PDAC) exhibits a desmoplastic stroma that can restrain or promote tumor, highlighting the need to selectively reprogram stromal states. This study identifies extravascular coagulation as an upstream regulator of fibrotic stroma via…
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