Science & ResearchJul 28, 2026
A p53-dependent FBXO44-RAD18 axis limits mutagenesis by terminating translesion DNA synthesis
DNA lesions continually challenge genome replication and threaten genome integrity.
DNA lesions continually challenge genome replication and threaten genome integrity. DNA damage tolerance pathways, including translesion DNA synthesis (TLS), allow cells to bypass lesions and prevent stalled forks from collapsing into double-strand breaks. Because TLS…
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