Assay concordance sets exact ceilings on what one biological score can predict

Computational models of biology are ranked by averaging one prediction against many experimental realizations of a phenotype that are treated as interchangeable.

Computational models of biology are ranked by averaging one prediction against many experimental realizations of a phenotype that are treated as interchangeable. We show this imposes an exact, model-free ceiling fixed by how much those realizations agree with each other, and…