Science & ResearchAug 29, 2026
ClC-7 links PIKfyve inhibition to Rab-dependent LRRK2 activity at lysosomes
Increased activity of leucine-rich repeat kinase 2 (LRRK2) confers Parkinson's disease risk.
Increased activity of leucine-rich repeat kinase 2 (LRRK2) confers Parkinson's disease risk. LRRK2 dynamically localizes to lysosomal membranes in response to various stresses, yet the mechanisms by which distinct lysosomal perturbations are communicated to LRRK2 remain unclear.…
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