A biased allosteric modulator is a molecular glue for β 2 AR dimerization.

Family A G-protein-coupled receptors (GPCRs) are typically described as monomers, yet growing evidence suggests that they can form dimers with distinct signalling properties 1-3 .

Family A G-protein-coupled receptors (GPCRs) are typically described as monomers, yet growing evidence suggests that they can form dimers with distinct signalling properties 1-3 . However, the mechanisms and therapeutic potential of such dimerization remain poorly understood.…