DCAF11-dependent molecular glue degrader activated by glutathionylation.

Targeted protein degradation is a powerful pharmacological strategy that harnesses the ubiquitin proteasome system to eliminate disease-relevant proteins, including otherwise undruggable proteins 1 .

Targeted protein degradation is a powerful pharmacological strategy that harnesses the ubiquitin proteasome system to eliminate disease-relevant proteins, including otherwise undruggable proteins 1 . Here we report an unbiased and broadly applicable platform for the systematic…