Science & ResearchAug 24, 2026
Direct visualization of MCM helicase activation and replisome coupling in situ
Deciphering the spatial organization of molecular machines that copy the genome remains a fundamental challenge in biology.
Deciphering the spatial organization of molecular machines that copy the genome remains a fundamental challenge in biology. Essential for eukaryotic DNA replication, Mini-Chromosome Maintenance (MCM2-7) helicases are loaded during G1 as double hexamers (DHs) to license…
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