Science & ResearchJul 16, 2026
Structure-based recasting of a mammalian DNA transpososomeas an obligate heterodimer
Eukaryotic DNA transpososomes assemble as nucleoprotein complexes containing multiple identical transposase protomers.
Eukaryotic DNA transpososomes assemble as nucleoprotein complexes containing multiple identical transposase protomers. We determined the structure of the hyperactive Myotis lucifugus piggyBat transpososome and discovered that it uses an unusual crescent-shaped, asymmetric…
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