Antimicrobial Combination Effects at Sub-inhibitory Doses do not Reliably Predict Effects at Inhibitory Concentrations

Assessing whether drug combinations synergise or antagonise is difficult for several reasons: (i) measuring bacterial death rates at clinically relevant inhibitory drug concentrations is methodologically challenging, (ii) there is no uni…

Assessing whether drug combinations synergise or antagonise is difficult for several reasons: (i) measuring bacterial death rates at clinically relevant inhibitory drug concentrations is methodologically challenging, (ii) there is no unifying definition of what constitutes…