Microtubule curling as an efficient readout to uncover fundamental concepts of axonal cell biology and neurodegeneration

Nerve fibres (aka axons) are the slender, up-to-meter-long processes of nerve cells that wire nervous systems.

Nerve fibres (aka axons) are the slender, up-to-meter-long processes of nerve cells that wire nervous systems. These delicate structures must survive for an organisms lifetime, making them prime lesion sites in neurodegeneration. Their long-term maintenance requires the…