Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging.

Aging disrupts tissue homeostasis across organ systems.

Aging disrupts tissue homeostasis across organ systems. Here, we identify tissue-resident macrophages (TRMs) as central coordinators of age-related organ decline through impaired clearance of senescent neutrophils, a process regulated by the immunomodulatory prostaglandin E2…