Glycolytic compensation rather than NAD+/NADH balance sustains neuronal function during mitochondrial stress

Neurons engage compensatory pathways that promote survival when confronted with mitochondrial dysfunction.

Neurons engage compensatory pathways that promote survival when confronted with mitochondrial dysfunction. Indeed, we recently showed that Drosophila neurons upregulate Ldh transcription to help survive the loss of the key mitochondrial fusion gene Opa1. Here, we further…