A binding-to-release strategy for targeted anticancer drug delivery.

Drug conjugates, such as antibody-drug conjugates (ADCs) and small molecule-drug conjugates (SMDCs), are often dependent on efficient receptor-mediated endocytosis for payload release 1-3 -supported by about 10% of targets 4-7 .

Drug conjugates, such as antibody-drug conjugates (ADCs) and small molecule-drug conjugates (SMDCs), are often dependent on efficient receptor-mediated endocytosis for payload release 1-3 -supported by about 10% of targets 4-7 . For poorly internalizing targets, drug conjugates…