Science & ResearchAug 30, 2026
Cryo-EM Structure of Duck Secretory IgM Reveals a Conserved Pentameric Assembly with Avian-Specific Features at Molecular Interfaces
IgM is the most ancient antibody isotype, playing an important role in both circulatory and mucosal immune responses across vertebrates, yet structural characterization of its polymeric forms is limited outside of mammals.
IgM is the most ancient antibody isotype, playing an important role in both circulatory and mucosal immune responses across vertebrates, yet structural characterization of its polymeric forms is limited outside of mammals. Here, we report the cryo-electron microscopy structure…
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