A cholinergic hub in the nucleus accumbens gates opioid-reward learning.

Beneficial and maladaptive opioid effects are difficult to dissociate 1-3 , partly because dopamine signalling contributes to both these effect types 4-13 .

Beneficial and maladaptive opioid effects are difficult to dissociate 1-3 , partly because dopamine signalling contributes to both these effect types 4-13 . Here we show that associative opioid-reward learning can be blocked even under conditions that elevate dopamine in the…