Single molecule studies of the bacterial curli protein CsgA reveal a structurally dynamic monomeric structure

E. coli curli, a critical biofilm scaffold and antimicrobial target, is assembled mainly from the protein CsgA guided by many other chaperones in a regulated functional amyloid assembly pathway. CsgA is highly aggregation prone, confound…

E. coli curli, a critical biofilm scaffold and antimicrobial target, is assembled mainly from the protein CsgA guided by many other chaperones in a regulated functional amyloid assembly pathway. CsgA is highly aggregation prone, confounding high-resolution studies of its…