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Science & ResearchAug 23, 2026

RapidMACS: MACS3-identical peak calling, 50x faster

Motivation: MACS3 is a comprehensive peak-calling toolkit whose subcommands span single- and paired-end data, narrow and broad peaks, and a range of signal-track utilities.

Motivation: MACS3 is a comprehensive peak-calling toolkit whose subcommands span single- and paired-end data, narrow and broad peaks, and a range of signal-track utilities. However, many ATAC-seq and multiomic pipelines, including our own, use just one of those capabilities:…

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