Single neurons detect spatiotemporal activity transitions through STP and EI imbalance

Sensory input and internal context converge onto the hippocampus as spatio-temporal activity patterns.

Sensory input and internal context converge onto the hippocampus as spatio-temporal activity patterns. Transitions in these input patterns are frequently salient. We demonstrate that short-term potentiation (STP) mediates escape from EI balance to implement mismatch detection in…