Sequence architecture shapes human allele frequencies through ectopic gene conversion

Population-genetic interpretations of allele frequency commonly begin from a single-origin assumption: that a variant arose once and was subsequently shaped by selection, drift and demographic history.

Population-genetic interpretations of allele frequency commonly begin from a single-origin assumption: that a variant arose once and was subsequently shaped by selection, drift and demographic history. Here we show that for a substantial fraction of human variation this…