Rb-driven transcription limits its tumour-suppressive effects in breast cancer.

The retinoblastoma protein (Rb) is a tumour suppressor best known for repressing E2F transcription factors and halting cell cycle progression 1 .

The retinoblastoma protein (Rb) is a tumour suppressor best known for repressing E2F transcription factors and halting cell cycle progression 1 . In hormone receptor-positive (HR + ) breast cancer, CDK4/6 inhibitors activate Rb by preventing its phosphorylation, forming a key…