Structural basis for monobody OP-4 binding to open-form adenylate kinase

Monobodies are fibronectin type-III-based binding proteins that specifically bind target proteins and regulate their functions.

Monobodies are fibronectin type-III-based binding proteins that specifically bind target proteins and regulate their functions. We previously identified monobodies that selectively recognize either the OPEN or CLOSED conformation of adenylate kinase (Adk), revealing that…