Enzymatic glycosylation and amidation reshapes polyene bioactivity.

Fungal diseases are an escalating threat to human health, driven by rising antimicrobial resistance and a lack of new antifungal treatments 1,2 .

Fungal diseases are an escalating threat to human health, driven by rising antimicrobial resistance and a lack of new antifungal treatments 1,2 . Polyenes, a class of complex natural products, have been widely used as antifungal agents due to their broad-spectrum activity 3 .…