Rescue schizophrenia-related phenotypes caused by Setd1a deficiency by histone demethylase inhibitors

Schizophrenia (SCZ) is a genetically complex neuropsychiatric disorder in which rare loss-of-function mutations in the histone methyltransferase SETD1A confer substantial risk.

Schizophrenia (SCZ) is a genetically complex neuropsychiatric disorder in which rare loss-of-function mutations in the histone methyltransferase SETD1A confer substantial risk. Although SETD1A haploinsufficiency had been linked to morphological, synaptic and behavioral…