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Science & ResearchJul 29, 2026

Rational design of disordered proteins for sequence-function investigation.

Despite lacking a stable three-dimensional structure, intrinsically disordered protein regions (IDRs) are ubiquitous across all kingdoms of life and have essential cellular roles 1 .

Despite lacking a stable three-dimensional structure, intrinsically disordered protein regions (IDRs) are ubiquitous across all kingdoms of life and have essential cellular roles 1 . While rational design of folded proteins has seen substantial recent progress 2 , our ability to…

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