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Science & ResearchSep 4, 2026

Design and experimental characterization of specificity-switching mutational paths of WW domains

Specific interactions between proteins and other biomolecules are ubiquitous in cellular processes.How specificity is encoded in the protein sequence and can be modified through a minimal set of concerted mutations is a complex issue.

Specific interactions between proteins and other biomolecules are ubiquitous in cellular processes.How specificity is encoded in the protein sequence and can be modified through a minimal set of concerted mutations is a complex issue. In this work, we focus on the WW protein…

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