Prior therapy defines mutation profiles in childhood cancer at relapse.

Children with cancer develop many short- and long-term side-effects of treatment 1 , but the amount of DNA damage associated with chemotherapy exposure is unclear 2 .

Children with cancer develop many short- and long-term side-effects of treatment 1 , but the amount of DNA damage associated with chemotherapy exposure is unclear 2 . Here we used mutational signatures to measure this damage using whole-genome-sequenced tumours from a…