Science & ResearchJul 30, 2026
Atlas of lysosomal aging reveals a metabolite signature shared with lysosomal storage disorders.
Lysosomal dysfunction is a well-recognized feature of aging.
Lysosomal dysfunction is a well-recognized feature of aging. Here, we used a suite of tools for rapid lysosomal isolation to construct a multitissue atlas of the metabolite changes lysosomes undergo during aging. Aged lysosomes in brain, heart, muscle, and white adipose tissue…
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