Mitochondrial metabolism and epigenetic crosstalk drive SASP.

Senescent cells promote tissue dysfunction in part through the senescence-associated secretory phenotype (SASP) 1 .

Senescent cells promote tissue dysfunction in part through the senescence-associated secretory phenotype (SASP) 1 . Cytosolic mitochondrial nucleic acids activate innate immune signalling to initiate this inflammatory programme 2,3 . Here we show that mitochondrial metabolism…