Rare variants drive high variance in human ancestral fitness at mutation-selection-drift balance

It is an open question whether variation in the genetic load of unconditionally deleterious mutations contributes substantially to the variability in human disease.

It is an open question whether variation in the genetic load of unconditionally deleterious mutations contributes substantially to the variability in human disease. Here, we solve for mutation-selection-drift balance and predict variation in genetic load given a realistic human…