p53 is a selective barrier to chromosome loss in cancer

Aneuploidy and TP53 mutations are among the most frequent genetic alterations in cancer.

Aneuploidy and TP53 mutations are among the most frequent genetic alterations in cancer. p53 inactivation is widely considered a key enabling event for aneuploidy emergence. However, whether p53 protects against specific types of aneuploidy, and whether this is universal across…