Pretraining Enhances Megabase-Scale Gene Expression Prediction with GeneUnet

Predicting gene expression from DNA sequence across diverse genomic tracks is essential for understanding gene regulation and interpreting non-coding variants.

Predicting gene expression from DNA sequence across diverse genomic tracks is essential for understanding gene regulation and interpreting non-coding variants. Existing supervised methods are limited to few species and fail to exploit conserved regulatory mechanisms, while DNA…